T cells and autoimmune diseases
نویسندگان
چکیده
منابع مشابه
Targeting T regulatory cells in autoimmune diseases.
Among the several mechanisms that play a role in maintaining peripheral self-tolerance is the existence of a unique CD4+CD25+ population of naturally occurring regulatory T cells, which actively prevent both the activation and the effector function of autoreactive T cells that have escaped different mechanisms of tolerance. Many studies have shown the benefit of targeting this cell population b...
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Complete List of Authors: Papp, Gábor; University of Debrecen Medical Center, Institute of Medicine, Department of Clinical Immunology Szabó, Krisztina; University of Debrecen Medical Center, Institute of Medicine, Department of Clinical Immunology Szekanecz, Zoltán; University of Debrecen Medical Center, Institute of Medicine, Department of Rheumatology Zeher, Margit; University of Debrecen Me...
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The regulatory T (Treg) cells play an important role in the maintenance of homeostasis and the prevention of autoimmune diseases. Although most studies are focusing on the role of Treg cells in T cells and T cells-mediated diseases, these cells also directly affect B cells and other non-T cells. This manuscript updates the role of Treg cells on the B cells and B cell-mediated diseases. In addit...
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Prior to the 1990s, genetic analyses indicated that many autoimmune diseases are driven by T cell responses; however, the identity of the pathogenic T cell populations responsible for dysfunctional autoimmune responses remained unclear. Some 20 years ago, the discovery of numerous chemokines and their receptors along with the development of specific mAbs to these provided a distinct advance. Th...
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Regulatory T-cells (Tregs) constitute a small subset of cells that are actively involved in maintaining self-tolerance, in immune homeostasis and in antitumor immunity. They are thought to play a significant role in the progression of cancer and are generally increased in patient with chronic lymphocytic leukemia (CLL). Their number correlates with more aggressive disease status and is predicti...
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ژورنال
عنوان ژورنال: Allergology International
سال: 2001
ISSN: 1323-8930
DOI: 10.1046/j.1440-1592.2001.00193.x